The system currently supports "versions" (for A/B testing) in the editor. I was surprised that I was not able to use this infrastructure to send different versions to different segments.

Example 1:
Send Version A to [Business Customers Segment]
Send Version B [Everyone Else]

Example 2:
Send Version A to [Customers Segment]
Send Version B to [Everyone Else]

Example 3:
Send Version A to [Customers Segment]
Send Version B to [Opened in the Last 30 Days Segment]
Send Version C to [Everyone Else]

Note: In the functionality described above I assume that is someone matches multiple segments then the first match takes priority. (In example 3, contacts who are in both the "Customers Segment" and "Opened in the Last 30 Days Segment" will get Version A)